Dendrimers
XiaO / 2013-11-28
Dendrimers
Dendrimers 由核心 (Initiator core),内部的多个支化官能团 (Interior) 和外部的表面基团 (Exterior) 三部分组成
Main Features
高度支化的结构 + 独特的单分散性
特点:
- 结构规整,分子结构精确;
- 相对分子质量可以控制;
- 具有大量的表面功能团;
- 高度的几何对称性;
- 球形分子外挤内松,分子内存在空腔并可调节。
- e.g.:
- 聚甲基丙烯酸甲酯
- 聚苯乙烯
- 聚乙炔
- 聚苯
- 聚噻吩
- 聚芴
- 聚对苯乙炔
- 聚对苯乙炔
- 聚硅氧烷
- 聚氧杂降冰片烯(polyoxanorbornene)
- 聚乙烯亚胺
Synthesise
Carboxylic acid and phenol terminated water soluble dendrimers were synthesised to establish their utility in drug delivery as well as conducting chemical reactions in their interiors. This might allow researchers to attach both targeting molecules and drug molecules to the same dendrimer, which could reduce negative side effects of medications on healthy cells.
- U.S. Dow Chemical Company — Dr. Tomalia
- South Florida University — Prof. Newkome
- Cornell University — J.M.J.Frechet Lab.